Article
Increased fibrosis and interstitial fluid pressure in two different types of syngeneic murine carcinoma grown in integrin β3-subunit deficient mice.
PloS one - 1 Jan 2012
Friman Tomas, Gustafsson Renata, Stuhr Linda B, Chidiac Jean, Heldin Nils-Erik, Reed Rolf K, Oldberg Ake, Rubin Kristofer
Abstract excerpt
Stroma properties affect carcinoma physiology and direct malignant cell development. Here we present data showing that α(V)β(3) expressed by stromal cells is involved in the control of interstitial fluid pressure (IFP), extracellular volume (ECV) and collagen scaffold architecture in experimental murine carcinoma. IFP was elevated and ECV lowered in syngeneic CT26 colon and LM3 mammary carcinomas grown in...
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