Semi-automatic in silico gap closure enabled de novo assembly of two Dehalobacter genomes from metagenomic data.

Abstract excerpt

Typically, the assembly and closure of a complete bacterial genome requires substantial additional effort spent in a wet lab for gap resolution and genome polishing. Assembly is further confounded by subspecies polymorphism when starting from metagenome sequence data. In this paper, we describe an in silico gap-resolution strategy that can substantially improve assembly. This strategy resolves assembly gaps in...

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