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Article

Characterization of Drosophila GDNF receptor-like and evidence for its evolutionarily conserved interaction with neural cell adhesion molecule (NCAM)/FasII.

PloS one - 1 Jan 2012

Kallijärvi Jukka, Stratoulias Vassilis, Virtanen Kristel, Hietakangas Ville, Heino Tapio I, Saarma Mart

Abstract excerpt

BACKGROUND: Glial cell line-derived neurotrophic factor (GDNF) family ligands are secreted growth factors distantly related to the TGF-β superfamily. In mammals, they bind to the GDNF family receptor α (Gfrα) and signal through the Ret receptor tyrosine kinase. In order to gain insight into the evolution of the Ret-Gfr-Gdnf signaling system, we have cloned and characterized the first invertebrate Gfr-like cDNA...

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Identifiers

PMID: 23284846
DOI: 10.1371/journal.pone.0051997
PMCID: PMC3527400

Genes

GDNF
GPI
RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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