Article
Cytomegalovirus resistance in solid organ transplant recipients treated with intravenous ganciclovir or oral valganciclovir.
Antiviral therapy - 1 Jan 2009
Boivin Guy, Goyette Nathalie, Rollag Halvor, Jardine Alan G, Pescovitz Mark D, Asberg Anders, Ives Jane, Hartmann Anders, Humar Atul
Abstract excerpt
BACKGROUND: The rate of cytomegalovirus (CMV) mutations conferring ganciclovir resistance was assessed in a trial comparing intravenous ganciclovir and oral valganciclovir for treatment of CMV disease in solid organ transplant (SOT) recipients. METHODS: Viral genes (UL97 and UL54) conferring ganciclovir resistance were amplified and sequenced from blood samples collected at days 0 (before therapy), 21 (end of...
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