Article
Rapid development of isolate-specific neutralizing antibodies after primary HIV-1 infection and consequent emergence of virus variants which resist neutralization by autologous sera.
AIDS (London, England) - 1 Feb 1990
Albert J, Abrahamsson B, Nagy K, Aurelius E, Gaines H, Nyström G, Fenyö E M
Abstract excerpt
The kinetics of appearance and specificity of HIV-1 neutralizing antibodies was studied in four individuals. HIV-1 was isolated during symptomatic primary HIV-1 infection and repeatedly thereafter, and tested against autologous sera collected in parallel. Our patients developed isolate-specific l...
Topics
- Acquired Immunodeficiency Syndrome
- Antibody Specificity
- Genetic Variation
- HIV Antibodies
- HIV-1
- Humans
- Male
- Neutralization Tests
- Time Factors