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Article

Detection of human papillomavirus in human focal cortical dysplasia type IIB

9 Nov 2012

Abstract excerpt

OBJECTIVE: Focal cortical dysplasia type IIB (FCDIIB) is a sporadic developmental malformation of the cerebral cortex highly associated with pediatric epilepsy. Balloon cells (BCs) in FCDIIB exhibit constitutive activation of the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway. Recently, the high-risk human papillomavirus type 16 oncoprotein E6 was identified as a potent activator of mTORC1...

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PMID: 23280839
DOI: 10.1002/ana.23795

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