Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Somatic mutations rather than viral infection classify focal cortical dysplasia type II as mTORopathy.

Current opinion in neurology - 1 Jun 2016

Blümcke Ingmar, Sarnat Harvey B

Abstract excerpt

PURPOSE OF REVIEW: Genetic studies in focal cortical dysplasia type II (FCD II) provided ample evidence for somatic mutations in genes associated with the mammalian target of rapamycin (mTOR) pathway. Interestingly, the mTOR pathway can also be activated by the E6 oncogene of human papilloma viruses, and available data in FCD II remain controversial. We review and discuss the contradicting etiologies. RECENT...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Proliferation
Share to Epilepsy
Share to Microtubule and mitosis dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Papillomavirus Infections

Share to PI3K/AKT/mTOR signaling in cancer

Share to TOR Serine-Threonine Kinases

Share to Tuberous Sclerosis Complex Research

Source

Identifiers

PMID: 26840044
DOI: 10.1097/WCO.0000000000000303

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Somatic mutations rather than viral infection classify focal cortical dysplasia type II as mTORopathy.PMID 26840044Read ↗

mTOR Pathway Somatic Pathogenic Variants in Focal Malformations of Cortical DevelopmentSemantic proximity Read ↗

Brain somatic mutations in MTOR leading to focal cortical dysplasia.Semantic proximity Read ↗

Hemispheric cortical dysplasia secondary to a mosaic somatic mutation in <i>MTOR</i>Semantic proximity Read ↗

Somatic Mutations in the MTOR gene cause focal cortical dysplasia type IIb.Semantic proximity Read ↗

Focal cortical dysplasia II caused by brain somatic mutation of IRS-1 is associated with ERK signaling pathway activation.Semantic proximity Read ↗

Cortical Dysplasia and the mTOR Pathway: How the Study of Human Brain Tissue Has Led to Insights into Epileptogenesis.Semantic proximity Read ↗

The role of somatic mutational events in the pathogenesis of epilepsySemantic proximity Read ↗

Somatic Mutations Activating the mTOR Pathway in Dorsal Telencephalic Progenitors Cause a Continuum of Cortical Dysplasias.Semantic proximity Read ↗

Focal cortical dysplasia: a practical guide for neurologists.Semantic proximity Read ↗

Brain Somatic Mutations in MTOR Disrupt Neuronal Ciliogenesis, Leading to Focal Cortical Dyslamination.Semantic proximity Read ↗

Brain somatic mutations in MTOR cause focal cortical dysplasia type II leading to intractable epilepsy.Semantic proximity Read ↗

Association of MTOR Mutations With Developmental Brain Disorders, Including Megalencephaly, Focal Cortical Dysplasia, and Pigmentary Mosaicism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.