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Article

A predictive clinical-genetic model of tissue plasminogen activator response in acute ischemic stroke.

Annals of neurology - 1 Nov 2012

del Río-Espínola Alberto, Fernández-Cadenas Israel, Giralt Dolors, Quiroga Adoracion, Gutiérrez-Agulló Maria, Quintana Manuel, Fernández-Álvarez Patricia, Domingues-Montanari Sophie, Mendióroz Maite, Delgado Pilar, Turck Natacha, Ruíz Agustin, Ribó Marc, Castellanos Mar, Obach Victor, Martínez Sergi, Freijo Mari Mar, Jiménez-Conde Jordi, Cuadrado-Godia Elisa, Roquer Jaume, Chacón Pilar, Martí-Fábregas Joan, Sánchez Jean Charles, Montaner Joan

Abstract excerpt

OBJECTIVE: Wide interindividual variability exists in response to tissue plasminogen activator (t-PA) treatment in the acute phase of ischemic stroke. We aimed to find genetic variations associated with hemorrhagic transformation (HT) and mortality rates after t-PA. We then generated a clinical-g...

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PMID: 23280790
DOI: 10.1002/ana.23664

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23280790-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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