Article
Household endotoxin levels and the risk of non-Hodgkin lymphoma.
Cancer causes & control : CCC - 1 Feb 2013
Wang Jun, Cozen Wendy, Thorne Peter S, Berhane Kiros, Cerhan James R, Hartge Patricia, Ward Mary H, De Roos Anneclaire J, Severson Richard K, Morton Lindsay M, Bernstein Leslie, Linet Martha S, Colt Joanne S
Abstract excerpt
OBJECTIVE: Endotoxin, a component of the outer membrane of gram-negative bacteria, elicits a strong innate and inflammatory immune response associated with the secretion of proinflammatory cytokines, including tumor necrosis factor-alpha (TNF-α). Because TNF-α polymorphisms that increase TNF-α production are associated with an increased risk of non-Hodgkin lymphoma (NHL), we hypothesized that increased levels of...
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