Article
Deep sequencing of the hepatitis B virus in hepatocellular carcinoma patients reveals enriched integration events, structural alterations and sequence variations.
Carcinogenesis - 1 Apr 2013
Toh Soo Ting, Jin Yu, Liu Lizhen, Wang Jingbo, Babrzadeh Farbod, Gharizadeh Baback, Ronaghi Mostafa, Toh Han Chong, Chow Pierce Kah-Hoe, Chung Alexander Y-F, Ooi London L-P-J, Lee Caroline G-L
Abstract excerpt
Chronic hepatitis B virus (HBV) infection is epidemiologically associated with hepatocellular carcinoma (HCC), but its role in HCC remains poorly understood due to technological limitations. In this study, we systematically characterize HBV in HCC patients. HBV sequences were enriched from 48 HCC...
Topics
- Amino Acid Substitution
- Base Sequence
- Carcinoma, Hepatocellular
- Cell Line
- Chromosomes, Human, Pair 10
- DNA, Viral
- Genetic Variation
- Hepatitis B virus
- Hepatitis B, Chronic
- High-Throughput Nucleotide Sequencing
- Humans
- Liver Neoplasms
- Promoter Regions, Genetic