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Article

Pharmacogenetic Factors Influence Escitalopram Pharmacokinetics and Adverse Events in Youth with a Family History of Bipolar Disorder: A Preliminary Study.

Journal of child and adolescent psychopharmacology - 1 Feb 2024

Honeycutt Duncan C, Blom Thomas J, Ramsey Laura B, Strawn Jeffrey R, Bruns Kaitlyn M, Welge Jeffrey A, Patino Luis R, Singh Manpreet K, DelBello Melissa P

Abstract excerpt

Introduction: Escitalopram is an effective and generally well-tolerated antidepressant, but children of parents with bipolar disorder (BD) may be at increased risk for adverse events associated with antidepressants, including increased irritability, restlessness, impulsivity, and manic symptoms. This risk may be influenced by polymorphisms in genes encoding cytochrome P450 enzymes (CYP2C19 or CYP2D6), the...

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Identifiers

PMID: 38377518
DOI: 10.1089/cap.2023.0073
PMCID: PMC10880264

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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