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Withaferin A, a Cytotoxic Steroid from <i>Vassobia breviflora</i>, Induces Apoptosis in Human Head and Neck Squamous Cell Carcinoma

20 Aug 2010

Abstract excerpt

As part of a program to discover drug leads from plant biodiversity, the present investigation was undertaken to explore the anticancer potential of compounds derived from selected Latin American plants. Bioassay-guided fractionation of a crude extract of the aerial parts of Vassobia breviflora led to the isolation of the withanolide-type steroidal lactone withaferin A (1). This compound was tested for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 20726569
DOI: 10.1021/np100112p

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