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Article

CCL2/MCP-1 controls parasite burden, cell infiltration, and mononuclear activation during acute Trypanosoma cruzi infection.

Journal of leukocyte biology - 1 Nov 2009

Paiva Cláudia N, Figueiredo Rodrigo T, Kroll-Palhares Karina, Silva Andrea A, Silvério Jaline C, Gibaldi Daniel, Pyrrho Alexandre Dos S, Benjamim Claudia F, Lannes-Vieira Joseli, Bozza Marcelo T

Abstract excerpt

CCL2/MCP-1 has emerged recently as a critical factor in infectious and autoimmune myocarditis. In fact, this chemokine is produced in great amounts in hearts from Trypanosoma cruzi-infected mice and is known to enhance parasite uptake and destruction by macrophages. Herein, we studied the involvement of CCL2 in tissue inflammation and resistance to T. cruzi. Infected CCL2(-/-) mice developed higher parasitemias...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19641038
DOI: 10.1189/jlb.0309187

Genes

CCL2
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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