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Article

Eph-B4 mediates vein graft adaptation by regulation of endothelial nitric oxide synthase.

Journal of vascular surgery - 1 Jan 2017

Wang Mo, Collins Michael J, Foster Trenton R, Bai Hualong, Hashimoto Takuya, Santana Jeans M, Shu Chang, Dardik Alan

Abstract excerpt

OBJECTIVE: Vein graft adaptation is characterized by loss of expression of the tyrosine kinase receptor Eph-B4, the embryonic determinant of venous identity, without increased expression of its ligand ephrin-B2, the embryonic determinant of arterial identity. Endothelial nitric oxide synthase (eNOS) is an important mediator of vessel remodeling. We hypothesized that the mechanism of action of Eph-B4 during vein...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26817610
DOI: 10.1016/j.jvs.2015.11.041
PMCID: PMC4958608

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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