Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rescue of Dysfunctional Autophagy Attenuates Hyperinflammatory Responses from Cystic Fibrosis Cells

22 Dec 2012

Abstract excerpt

A hallmark feature of cystic fibrosis (CF) is progressive pulmonary obstruction arising from exaggerated host proinflammatory responses to chronic bacterial airway colonization. The mechanisms for these heightened inflammatory responses have been only partially characterized, hampering development of effective anti-inflammatory therapies. The aim of this study was to identify and validate novel dysfunctional...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Extracellular vesicles in disease
Share to Studies on Chitinases and Chitosanases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23264659
DOI: 10.4049/jimmunol.1201404

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rescue of Dysfunctional Autophagy Attenuates Hyperinflammatory Responses from Cystic Fibrosis CellsPMID 23264659Read ↗

Bacterial Subversion of Autophagy in Cystic FibrosisSemantic proximity Read ↗

Epithelial Atg5 Deficiency Intensifies Caspase‐11 Activation, Fueling Extracellular mtDNA Release to Activate cGAS–STING–NLRP3 Axis in Macrophages During Pseudomonas InfectionSemantic proximity Read ↗

Atypical Activation of the Unfolded Protein Response in Cystic Fibrosis Airway Cells Contributes to p38 MAPK-Mediated Innate Immune ResponsesSemantic proximity Read ↗

Immune response of polarized cystic fibrosis airway epithelial cells infected with Influenza A virusSemantic proximity Read ↗

microRNA-181b is increased in cystic fibrosis cells and impairs lipoxin A4 receptor-dependent mechanisms of inflammation resolution and antimicrobial defenseSemantic proximity Read ↗

Autophagy stimulation by rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis.Semantic proximity Read ↗

Goblet cell breakdown: transcriptomics reveals Acinetobacter baumannii early and robust inflammatory response in differentiated human bronchial epithelial cellsSemantic proximity Read ↗

CAGE sequencing reveals CFTR-dependent dysregulation of type I IFN signaling in activated cystic fibrosis macrophages.Semantic proximity Read ↗

Metabolic Reprograming of Cystic Fibrosis Macrophages via the IRE1α Arm of the Unfolded Protein Response Results in Exacerbated InflammationSemantic proximity Read ↗

Pseudomonas toxin pyocyanin triggers autophagy: Implications for pathoadaptive mutations.Semantic proximity Read ↗

Distinctive lipid signatures of bronchial epithelial cells associated with cystic fibrosis drugs, including TrikaftaSemantic proximity Read ↗

Cystic Fibrosis from Laboratory to Bedside: The Role of A20 in NF-κB-Mediated Inflammation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.