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Article

JAKing up hematopoietic proliferation.

Cancer cell - 1 Apr 2005

Shannon Kevin, Van Etten Richard A

Abstract excerpt

Mutations that deregulate proliferation and survival pathways have emerged as a common molecular theme in the pathogenesis of myeloproliferative disorders (MPDs). Three studies now report an amino acid substitution in the JAK2 kinase in most patients with polycythemia vera as well as in some cases of essential thrombocythemia and chronic idiopathic myelofibrosis. Functional analysis demonstrates that this...

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Source

Identifiers

PMID: 15837617
DOI: 10.1016/j.ccr.2005.04.002

Genes

JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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