Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular diagnostics of a single multifocal non-small cell lung cancer case using targeted next generation sequencing.

Virchows Archiv : an international journal of pathology - 1 Feb 2013

Geurts-Giele Willemina R R, Dirkx-van der Velden Albertina W, Bartalits Natascha M M T, Verhoog Leon C, Hanselaar Wessel E J J, Dinjens Winand N M

Abstract excerpt

Histological and molecular subtyping of non-small cell lung cancer (NSCLC) is important for predicting survival and drug response in these patients. Up to 8 % of NSCLC are multifocal and these tumor foci are often clonally related. Multiple foci can however also represent different primary tumors, with prognostic and therapeutic consequences. We describe a patient with multifocal NSCLC from which we obtained...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Base Sequence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Non-Small-Cell Lung

Share to ErbB Receptors

Share to Lung Neoplasms

Share to Mutation

Share to Pathology, Molecular

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 23262782
DOI: 10.1007/s00428-012-1346-4

Genes

EGFR
ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular diagnostics of a single multifocal non-small cell lung cancer case using targeted next generation sequencing.PMID 23262782Read ↗

Using molecular characteristics to distinguish multiple primary lung cancers and intrapulmonary metastases.Semantic proximity Read ↗

Genomic and Clinical Significance of Multiple Primary Lung Cancers as Determined by Next-Generation Sequencing.Semantic proximity Read ↗

EGFR-Mutant Non-Small Cell Lung Cancer in the Era of Precision Medicine: Importance of Germline EGFR T790M Testing.Semantic proximity Read ↗

Molecular profiling of key driver genes improves staging accuracy in multifocal non-small cell lung cancer.Semantic proximity Read ↗

Mutational analysis of multiple lung cancers: Discrimination between primary and metastatic lung cancers by genomic profile.Semantic proximity Read ↗

Comprehensive Next-Generation Sequencing Unambiguously Distinguishes Separate Primary Lung Carcinomas From Intrapulmonary Metastases: Comparison with Standard Histopathologic ApproachSemantic proximity Read ↗

Next-generation sequencing facilitates differentiating between multiple primary lung cancer and intrapulmonary metastasis: a case series.Semantic proximity Read ↗

From Uniplex to Multiplex Molecular Profiling in Advanced Non-Small Cell Lung Carcinoma.Semantic proximity Read ↗

Clonality of multifocal nonsmall cell lung cancer: implications for staging and therapy.Semantic proximity Read ↗

Targeted deep sequencing helps distinguish independent primary tumors from intrapulmonary metastasis for lung cancer diagnosis.Semantic proximity Read ↗

Towards the molecular era of discriminating multiple lung cancersSemantic proximity Read ↗

The prognostic effect of single and multiple cancer-related somatic mutations in resected non-small-cell lung cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.