Article
Flavan-3-ol compounds prevent pentylenetetrazol-induced oxidative damage in rats without producing mutations and genotoxicity.
Neuroscience letters - 8 Feb 2013
Scola Gustavo, Scheffel Thamiris, Gambato Gabriela, Freitas Suzana, Dani Caroline, Funchal Claudia, Gomez Rosane, Coitinho Adriana, Salvador Mirian
Abstract excerpt
Seizure disorder is a chronic condition in the brain that affects approximately 50 million people worldwide. Oxidative stress plays a crucial role in the pathophysiology of this disorder and can cause neuronal injury. Approximately one in three treated patients suffers from seizures regardless of pharmacological intervention, which results in oxidative damage. The present study aims to investigate the possible...
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