Article

Upregulated ONECUT2 impeded the efficacy of 5-FU treatment to relapsed patients and might be an emerging indicator of chemotherapy in gastric cancer

2022-05-10

Abstract excerpt

<h4>Background: </h4> Chemotherapeutic resistance is a main obstacle for prolonging the lifetime of gastric cancer (GC) patients, so new emerging solutions still remain to be investigated. We aim to identify an effective target, ONECTU2, for chemotherapy of GC patient, particularly relapsed patients. <h4>Methods: </h4>: STAD patients matched with clinical features and transcriptome sequencing data from TCGA were u...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 68e5b258-ac1a-5d4a-aeb0-8716e493a35f
DOI: 10.21203/rs.3.rs-1497914/v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Upregulated ONECUT2 impeded the efficacy of 5-FU treatment to relapsed patients and might be an emerging indicator of chemotherapy in gastric cancerDOI 10.21203/rs.3.rs-1497914/v2Read

Identification of gene signatures and potential therapeutic targets for acquired chemotherapy resistance in gastric cancer patientsSemantic proximity Read

A Shortcut From Genome to Drug: The Employment of Bioinformatic Tools to Find New Targets for Gastric Cancer TreatmentSemantic proximity Read

Personalized drug screening using patient-derived organoid and its clinical relevance in gastric cancerSemantic proximity Read

Long Non-Coding RNA in Gastric Cancer: Mechanisms and Clinical Implications for Drug ResistanceSemantic proximity Read

“3G” Trial: An RNA Editing Signature for Guiding Gastric Cancer ChemotherapySemantic proximity Read

Molecular Bases of Mechanisms Accounting for Drug Resistance in Gastric AdenocarcinomaSemantic proximity Read

A Predictive Signature for Oxaliplatin and 5-fluorouracil Based Chemotherapy Inlocally Advanced Gastric CancerSemantic proximity Read

Expression of sushi domain containing two reflects the malignant potential of gastric cancerSemantic proximity Read

A novel TOX3-WDR5-ABCG2 signaling axis regulates the progression of colorectal cancer by accelerating stem-like traits and chemoresistanceSemantic proximity Read

Establishment of panapoptotic gene signatures of platinum-chemotherapy to predict the response of chemotherapeutic drug resistance in gastric cancerSemantic proximity Read

Prognostic Autophagy-Related Genes of Gastric Cancer Patients on ChemotherapySemantic proximity Read

Integrated In silico and 3D Spheroid Models Reveal Key Genes and MiRNAs Driving Cisplatin/5-FU Resistance and Metastatic Potential in Gastric CancerSemantic proximity Read