Article
Genomic alterations in BCL2L1 and DLC1 contribute to drug sensitivity in gastric cancer.
Proceedings of the National Academy of Sciences of the United States of America - 6 Oct 2015
Park Hansoo, Cho Sung-Yup, Kim Hyerim, Na Deukchae, Han Jee Yun, Chae Jeesoo, Park Changho, Park Ok-Kyoung, Min Seoyeon, Kang Jinjoo, Choi Boram, Min Jimin, Kwon Jee Young, Suh Yun-Suhk, Kong Seong-Ho, Lee Hyuk-Joon, Liu Edison T, Kim Jong-Il, Kim Sunghoon, Yang Han-Kwang, Lee Charles
Abstract excerpt
Gastric cancer (GC) is the third leading cause of cancer-related deaths worldwide. Recent high-throughput analyses of genomic alterations revealed several driver genes and altered pathways in GC. However, therapeutic applications from genomic data are limited, largely as a result of the lack of druggable molecular targets and preclinical models for drug selection. To identify new therapeutic targets for GC, we...
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