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Article

Senescence-associated secretory phenotype favors the emergence of cancer stem-like cells.

Cell death & disease - 20 Dec 2012

Cahu J, Bustany S, Sola B

Abstract excerpt

The molecular mechanisms underlying cancer resistance remain elusive. One possible explanation is that cancer stem cells (CSCs) elude drug treatment, emerge and reproduce a tumor. Using multiple myeloma as a paradigm, we showed that cancer stem-like cells (CSLCs) appear after genotoxic stress because of their intrinsic properties. However, these properties do not drive the emergence of the CSLCs. Following...

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Identifiers

PMID: 23254289
DOI: 10.1038/cddis.2012.183
PMCID: PMC3542619

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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