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Article

Hexachlorophene is a potent KCNQ1/KCNE1 potassium channel activator which rescues LQTs mutants.

PloS one - 1 Jan 2012

Zheng Yueming, Zhu Xuejing, Zhou Pingzheng, Lan Xi, Xu Haiyan, Li Min, Gao Zhaobing

Abstract excerpt

The voltage-gated KCNQ1 potassium channel is expressed in cardiac tissues, and coassembly of KCNQ1 with an auxiliary KCNE1 subunit mediates a slowly activating current that accelerates the repolarization of action potential in cardiomyocytes. Mutations of KCNQ1 genes that result in reduction or loss of channel activity cause prolongation of repolarization during action potential, thereby causing long QT syndrome...

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Source

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Identifiers

PMID: 23251633
DOI: 10.1371/journal.pone.0051820
PMCID: PMC3520906

Genes

KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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