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Article

Portal, but not lobular, macrophages express matrix metalloproteinase-9: association with the ductular reaction and fibrosis in chronic hepatitis C.

Liver international : official journal of the International Association for the Study of the Liver - 1 Apr 2013

Gadd Victoria L, Melino Michelle, Roy Sandrine, Horsfall Leigh, O'Rourke Peter, Williams Millicent R, Irvine Katharine M, Sweet Matthew J, Jonsson Julie R, Clouston Andrew D, Powell Elizabeth E

Abstract excerpt

BACKGROUND: Liver macrophages are a heterogeneous cell population that produces factors involved in fibrogenesis and matrix turnover, including matrix metalloproteinase (MMP) -9. During liver injury, their close proximity to hepatic progenitor cells and the ductular reaction may enable them to regulate liver repair and fibrosis. AIMS: To enumerate and characterise liver macrophages in patients with chronic...

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Share to Antigens, Differentiation, Myelomonocytic
Share to Bile Ducts, Intrahepatic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD163 Antigen

Share to Hepatitis C, Chronic

Share to Liver Cirrhosis

Share to Matrix Metalloproteinase 9

Share to Receptors, CCR2

Share to Receptors, Cell Surface

Source

Identifiers

PMID: 23240894
DOI: 10.1111/liv.12050

Genes

CCR2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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