Article
Fibrosis correlates with a ductular reaction in hepatitis C: roles of impaired replication, progenitor cells and steatosis.
Hepatology (Baltimore, Md.) - 1 Apr 2005
Clouston Andrew D, Powell Elizabeth E, Walsh Meagan J, Richardson Michelle M, Demetris A Jake, Jonsson Julie R
Abstract excerpt
The mechanisms for progressive fibrosis and exacerbation by steatosis in patients with chronic hepatitis C (HCV) are still unknown. We hypothesized that proliferative blockade in HCV-infected and steatotic hepatocytes results in the default activation of hepatic progenitor cells (HPC), capable of differentiating into both biliary and hepatocyte lineages, and that the resultant ductular reaction promotes portal...
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