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Article

Segmental duplications in genome-wide significant loci and housekeeping genes; warning for GAPDH and ACTB.

Neurobiology of aging - 1 Jun 2013

Ghani Mahdi, Sato Christine, Rogaeva Ekaterina

Abstract excerpt

Normalizing quantitative polymerase chain reaction (qPCR) data to a housekeeping gene is a critical step in qPCR analyses. Our bioinformatics analysis of 1978 housekeeping genes revealed that 348 of them, including GAPDH and ACTB, are not reliable normalizers for qPCR validation of genomic copy number variants because they overlap highly homologous segmental duplications. For RNA-based qPCR, it is also critical...

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Source

Identifiers

PMID: 23238109
DOI: 10.1016/j.neurobiolaging.2012.11.006

Genes

ACTB
GAPDH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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