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Article

Entpd5 is essential for skeletal mineralization and regulates phosphate homeostasis in zebrafish.

Proceedings of the National Academy of Sciences of the United States of America - 26 Dec 2012

Huitema Leonie F A, Apschner Alexander, Logister Ive, Spoorendonk Kirsten M, Bussmann Jeroen, Hammond Chrissy L, Schulte-Merker Stefan

Abstract excerpt

Bone mineralization is an essential step during the embryonic development of vertebrates, and bone serves vital functions in human physiology. To systematically identify unique gene functions essential for osteogenesis, we performed a forward genetic screen in zebrafish and isolated a mutant, no bone (nob), that does not form any mineralized bone. Positional cloning of nob identified the causative gene to encode...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23236130
DOI: 10.1073/pnas.1214231110
PMCID: PMC3535636

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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