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Ethnic group‐related differences in CpG hypermethylation of the <i>GSTP1</i> gene promoter among African‐American, Caucasian and Asian patients with prostate cancer

30 Mar 2005

Abstract excerpt

The incidence and mortality of prostate cancer (PC) is approximately 2-fold higher among African-Americans as compared to Caucasians and very low in Asian. We hypothesize that inactivation of GSTP1 genes through CpG methylation plays a role in the pathogenesis of PC, and its ability to serve as a diagnostic marker that differs among ethnic groups. GSTP1 promoter hypermethylation and its correlation with...

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PMID: 15800905
DOI: 10.1002/ijc.21017

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