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Article

The ATPase activity of reptin is required for its effects on tumor cell growth and viability in hepatocellular carcinoma.

Molecular cancer research : MCR - 1 Feb 2013

Grigoletto Aude, Neaud Véronique, Allain-Courtois Nathalie, Lestienne Patrick, Rosenbaum Jean

Abstract excerpt

Reptin is overexpressed in most human hepatocellular carcinomas. Reptin is involved in chromatin remodeling, transcription regulation, or supramolecular complexes assembly. Its silencing leads to growth arrest and apoptosis in cultured hepatocellular carcinoma cells and stops hepatocellular carcinoma progression in xenografts. Reptin has an ATPase activity linked to Walker A and B domains. It is unclear whether...

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PMID: 23233483
DOI: 10.1158/1541-7786.MCR-12-0455

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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