Article
Oncogenic role of rab escort protein 1 through EGFR and STAT3 pathway.
Cell death & disease - 23 Feb 2017
Yun Un-Jung, Sung Jee Young, Park Seog-Yun, Ye Sang-Kyu, Shim Jaegal, Lee Jae-Seon, Hibi Masahiko, Bae Young-Ki, Kim Yong-Nyun
Abstract excerpt
Rab escort protein-1 (REP1) is linked to choroideremia (CHM), an X-linked degenerative disorder caused by mutations of the gene encoding REP1 (CHM). REP1 mutant zebrafish showed excessive cell death throughout the body, including the eyes, indicating that REP1 is critical for cell survival, a hallmark of cancer. In the present study, we found that REP1 is overexpressed in human tumor tissues from cervical, lung,...
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