Article
Extragenic suppressor mutations that restore twitching motility to fimL mutants of Pseudomonas aeruginosa are associated with elevated intracellular cyclic AMP levels.
MicrobiologyOpen - 1 Dec 2012
Nolan Laura M, Beatson Scott A, Croft Larry, Jones Peter M, George Anthony M, Mattick John S, Turnbull Lynne, Whitchurch Cynthia B
Abstract excerpt
Cyclic AMP (cAMP) is a signaling molecule that is involved in the regulation of multiple virulence systems of the opportunistic pathogen Pseudomonas aeruginosa. The intracellular concentration of cAMP in P. aeruginosa cells is tightly controlled at the levels of cAMP synthesis and degradation through regulation of the activity and/or expression of the adenylate cyclases CyaA and CyaB or the cAMP phosphodiesterase...
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