Article
Drosophila modifier screens to identify novel neuropsychiatric drugs including aminergic agents for the possible treatment of Parkinson's disease and depression.
Molecular psychiatry - 1 Feb 2014
Lawal H O, Terrell A, Lam H A, Djapri C, Jang J, Hadi R, Roberts L, Shahi V, Chou M-T, Biedermann T, Huang B, Lawless G M, Maidment N T, Krantz D E
Abstract excerpt
Small molecules that increase the presynaptic function of aminergic cells may provide neuroprotection in Parkinson's disease (PD) as well as treatments for attention deficit hyperactivity disorder (ADHD) and depression. Model genetic organisms such as Drosophila melanogaster may enhance the detection of new drugs via modifier or 'enhancer/suppressor' screens, but this technique has not been applied to processes...
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