Article
Pituitary adenylate cyclase-activating polypeptide (PACAP) can act as determinant of the tyrosine hydroxylase phenotype of dopaminergic cells during retina development.
Brain research. Developmental brain research - 12 May 2005
Borba Juliana Carrazzoni, Henze Isabela Pereira, Silveira Mariana Souza, Kubrusly Regina Célia Cussa, Gardino Patrícia Franca, de Mello Maria Christina Fialho, Hokoç Jan Nora, de Mello Fernando Garcia
Abstract excerpt
In the chick retina, dopaminergic cells are generated between embryonic days 3 and 7 (E3/E7). However, the expression of tyrosine hydroxylase (TH), the first enzyme in the catecholamine synthetic pathway, is only detected after E11/E12. During the interval comprising E7 to E12, signals conveyed by cAMP are important to determine the TH phenotype. The present study shows that pituitary adenylyl cyclase-activating...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.