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Article

Hepatitis C virus mediated changes in miRNA-449a modulates inflammatory biomarker YKL40 through components of the NOTCH signaling pathway.

PloS one - 1 Jan 2012

Sarma Nayan J, Tiriveedhi Venkataswarup, Subramanian Vijay, Shenoy Surendra, Crippin Jeffrey S, Chapman William C, Mohanakumar Thalachallour

Abstract excerpt

Liver disease due to hepatitis C virus (HCV) infection is an important health problem worldwide. HCV induced changes in microRNAs (miRNA) are shown to mediate inflammation leading to liver fibrosis. Gene expression analyses identified dysregulation of miRNA-449a in HCV patients but not in alcoholic and non-alcoholic liver diseases. By sequence analysis of the promoter for YKL40, an inflammatory marker upregulated...

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Identifiers

PMID: 23226395
DOI: 10.1371/journal.pone.0050826
PMCID: PMC3511274

Genes

NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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