Article
YKL-40 genetic polymorphisms and the risk of liver disease progression in patients with advanced fibrosis due to chronic hepatitis C.
Liver international : official journal of the International Association for the Study of the Liver - 1 Apr 2012
Fontana Robert J, Litman Heather J, Dienstag Jules L, Bonkovsky Herbert L, Su Grace, Sterling Richard K, Lok Anna S
Abstract excerpt
BACKGROUND/AIMS: The aim of this study was to explore the association of a functional YKL-40 promoter polymorphism (rs4950928) with baseline disease stage, response to antiviral therapy and risk of liver disease progression in a group of patients with chronic hepatitis C (CHC). METHODS: YKL-40 promoter polymorphisms were determined in 456 Hepatitis C Antiviral Long-term Treatment against Cirrhosis (HALT-C) Trial...
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