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Article

Novel Smad proteins localize to IR-induced double-strand breaks: interplay between TGFβ and ATM pathways

5 Dec 2012

Abstract excerpt

Cellular damage from ionizing radiation (IR) is in part due to DNA damage and reactive oxygen species, which activate DNA damage response (DDR) and cytokine signaling pathways, including the ataxia telangiectasia mutated (ATM) and transforming growth factor (TGF)β/Smad pathways. Using classic double-strand breaks (DSBs) markers, we studied the roles of Smad proteins in DDR and the crosstalk between TGFβ and ATM...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23221633
DOI: 10.1093/nar/gks1038

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