Article
White matter integrity as an intermediate phenotype: exploratory genome-wide association analysis in individuals at high risk of bipolar disorder.
Psychiatry research - 30 Apr 2013
Sprooten Emma, Fleming Kathryn M, Thomson Pippa A, Bastin Mark E, Whalley Heather C, Hall Jeremy, Sussmann Jess E, McKirdy James, Blackwood Douglas, Lawrie Stephen M, McIntosh Andrew M
Abstract excerpt
White matter integrity, as measured using diffusion tensor imaging (DTI), is reduced in individuals with bipolar disorder (BD), their unaffected relatives and carriers of specific risk-alleles. Fractional anisotropy (FA), an index of white matter integrity, is highly heritable but the genetic architecture of this trait has received little investigation. In this study we performed a genome-wide association study...
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