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Staphylococcus aureus autoinducer-2 quorum sensing decreases biofilm formation in an icaR-dependent manner

1 Dec 2012

Abstract excerpt

BACKGROUND: Staphylococcus aureus is an important pathogen that causes biofilm-associated infection in humans. Autoinducer 2 (AI-2), a quorum-sensing (QS) signal for interspecies communication, has a wide range of regulatory functions in both Gram-positive and Gram-negative bacteria, but its exact role in biofilm formation in S. aureus remains unclear. RESULTS: Here we demonstrate that mutation of the AI-2...

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PMID: 23216979
DOI: 10.1186/1471-2180-12-288

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