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Article

AI-2 of Aggregatibacter actinomycetemcomitans inhibits Candida albicans biofilm formation.

Frontiers in cellular and infection microbiology - 1 Jan 2014

Bachtiar Endang W, Bachtiar Boy M, Jarosz Lucja M, Amir Lisa R, Sunarto Hari, Ganin Hadas, Meijler Michael M, Krom Bastiaan P

Abstract excerpt

Aggregatibacter actinomycetemcomitans, a Gram-negative bacterium, and Candida albicans, a polymorphic fungus, are both commensals of the oral cavity but both are opportunistic pathogens that can cause oral diseases. A. actinomycetemcomitans produces a quorum-sensing molecule called autoinducer-2 (AI-2), synthesized by LuxS, that plays an important role in expression of virulence factors, in intra- but also in...

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PMID: 25101248
DOI: 10.3389/fcimb.2014.00094
PMCID: PMC4104835

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