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Article

Ebola virus genome plasticity as a marker of its passaging history: a comparison of in vitro passaging to non-human primate infection.

PloS one - 1 Jan 2012

Kugelman Jeffrey R, Lee Michael S, Rossi Cynthia A, McCarthy Sarah E, Radoshitzky Sheli R, Dye John M, Hensley Lisa E, Honko Anna, Kuhn Jens H, Jahrling Peter B, Warren Travis K, Whitehouse Chris A, Bavari Sina, Palacios Gustavo

Abstract excerpt

To identify polymorphic sites that could be used as biomarkers of Ebola virus passage history, we repeatedly amplified Ebola virus (Kikwit variant) in vitro and in vivo and performed deep sequencing analysis of the complete genomes of the viral subpopulations. We then determined the sites undergo...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23209706
DOI: 10.1371/journal.pone.0050316
PMCID: PMC3509072

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-23209706-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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