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Article

Hedgehog regulates Norrie disease protein to drive neural progenitor self-renewal.

Human molecular genetics - 1 Mar 2013

McNeill Brian, Mazerolle Chantal, Bassett Erin A, Mears Alan J, Ringuette Randy, Lagali Pamela, Picketts David J, Paes Kim, Rice Dennis, Wallace Valerie A

Abstract excerpt

Norrie disease (ND) is a congenital disorder characterized by retinal hypovascularization and cognitive delay. ND has been linked to mutations in 'Norrie Disease Protein' (Ndp), which encodes the secreted protein Norrin. Norrin functions as a secreted angiogenic factor, although its role in neural development has not been assessed. Here, we show that Ndp expression is initiated in retinal progenitors in response...

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PMID: 23201751
DOI: 10.1093/hmg/dds505

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