Article
Influence of genetic and non-genetic factors on the plasma concentrations of the clopidogrel metabolite (SR26334) among Chinese patients.
Clinica chimica acta; international journal of clinical chemistry - 1 Feb 2013
Zhou Haoming, Meng Shu, Zhao Jun, Dong Jinkun, Xu Ajing, Wang Fang, Guzalnur Tursun, Xin Junfen, Zhang Jian, Wang Jianhua, Cai Weimin
Abstract excerpt
The objective of this study was to investigate the contribution of genetic polymorphism of cytochrome P450 2C19 gene (CYP2C19) and non-genetic factors to clopidogrel in Chinese patients by using the plasma concentrations of SR26334 as a surrogate. A total of 150 patients who received clopidogrel therapy were enrolled in this study. Genotyping was carried out to identify the alleles of CYP2C19*2 and CYP2C19*3 by...
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