Article
PGC-1 coactivators regulate MITF and the tanning response.
Molecular cell - 10 Jan 2013
Shoag Jonathan, Haq Rizwan, Zhang Mingfeng, Liu Laura, Rowe Glenn C, Jiang Aihua, Koulisis Nicole, Farrel Caitlin, Amos Christopher I, Wei Qingyi, Lee Jeffrey E, Zhang Jiangwen, Kupper Thomas S, Qureshi Abrar A, Cui Rutao, Han Jiali, Fisher David E, Arany Zoltan
Abstract excerpt
The production of pigment by melanocytes tans the skin and protects against skin cancers. UV-exposed keratinocytes secrete α-MSH, which then activates melanin formation in melanocytes by inducing the microphthalmia-associated transcription factor (MITF). We show that PPAR-γ coactivator (PGC)-1α a...
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