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Array-based comparative genomic hybridization for genomic-wide screening of DNA copy number alterations in aggressive bone tumors

30 Nov 2012

Abstract excerpt

BACKGROUND: The genetic pathways of aggressive changes of bone tumors are still poorly understood. It is very important to analyze DNA copy number alterations (DCNAs), to identify the molecular events in the step of progression to the aggressive change of bone tissue. METHODS: Genome-wide array-based comparative genomic hybridization (array CGH) was used to investigate DCNAs of 14 samples from 13 aggressive bone...

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PMID: 23199169
DOI: 10.1186/1756-9966-31-100

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