Article
Decrease in proportion of CD19+ CD24(hi) CD27+ B cells and impairment of their suppressive function in Graves' disease.
PloS one - 1 Jan 2012
Zha Bingbing, Wang Luman, Liu Xiaoming, Liu Jun, Chen Zaoping, Xu Jiong, Sheng Li, Li Yiming, Chu Yiwei
Abstract excerpt
IL-10-producing B cells (B10 cells) have been shown to play a suppressive role in the peripheral blood of humans, with their numbers and function altered in several autoimmune diseases. However, the role of B10 cells in Graves' disease (GD) remains unknown. In this study, we demonstrated that B10 cells in human peripheral blood belonged to a CD24(hi)CD27(+) B cell subpopulation. The proportion of B10 cells along...
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