Article
Episialin, a carcinoma-associated mucin, is generated by a polymorphic gene encoding splice variants with alternative amino termini.
The Journal of biological chemistry - 5 Apr 1990
Ligtenberg M J, Vos H L, Gennissen A M, Hilkens J
Abstract excerpt
Episialin is a mucin-type glycoprotein present at the luminal side of most glandular epithelial cells. We have isolated cDNA clones encoding episialin and determined the structure of the gene. The gene encodes a transmembrane protein which consists of, for the greater part, tandem repeats of 20 a...
Topics
- Amino Acid Sequence
- Base Sequence
- Breast Neoplasms
- Cloning, Molecular
- Codon
- DNA
- Exons
- Genetic Variation
- Humans
- Introns
- Membrane Glycoproteins
- Molecular Sequence Data
- Mucin-1
- Neoplasm Proteins
- Polymorphism, Genetic
- RNA Splicing
- Repetitive Sequences, Nucleic Acid
- Restriction Mapping