Article
A single nucleotide polymorphism in an exon dictates allele dependent differential splicing of episialin mRNA.
Nucleic acids research - 25 Jan 1991
Ligtenberg M J, Gennissen A M, Vos H L, Hilkens J
Abstract excerpt
The episialin gene (MUC1) encodes an epithelial mucin containing a variable number of repeats with a length of twenty amino acids, resulting in many different alleles that can be subdivided into two size classes. The episialin pre-mRNA uses either one of two neighbouring splice acceptor sites for exon 2, which mainly encodes the repeats. Using the genetic polymorphism of the episialin gene to identify different...
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