Article
Prevalence of transmitted HIV-1 drug resistance mutations in children and adolescents in São Paulo, Brazil.
The Pediatric infectious disease journal - 1 Dec 2012
Almeida Flávia Jacqueline, Rodrigues Rosangela, Zaparoli Mayra Simioni, Berezin Eitan Naaman, Sáfadi Marco Aurélio Palazzi, de Paula Ferreira João Leandro, Lança André Minhoto, de Macedo Brígido Luis Fernando
Abstract excerpt
HIV drug resistance genotype testing, performed on 39 HIV-infected treatment-naive children from 2000 to 2011, identified 5 children (12.8%) with drug resistance mutations: 5.3% to nucleoside reverse transcriptase inhibitors, 5.3% to nonnucleoside reverse transcriptase inhibitors and 7.7% to protease inhibitors. There was a trend for increasing prevalence of drug resistance mutations during the 11-year study period.
Topics
- Adolescent
- Brazil
- Child
- Child, Preschool
- Drug Resistance, Viral
- Female
- Genotype
- HIV Infections
- HIV-1
- Humans
- Infant
- Infant, Newborn
- Male
- Mutation, Missense