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Article

The alarmin Mrp8/14 as regulator of the adaptive immune response during allergic contact dermatitis.

The EMBO journal - 9 Jan 2013

Petersen Beatrix, Wolf Marc, Austermann Judith, van Lent Peter, Foell Dirk, Ahlmann Martina, Kupas Verena, Loser Karin, Sorg Clemens, Roth Johannes, Vogl Thomas

Abstract excerpt

Mrp8 and Mrp14 are endogenous alarmins amplifying inflammation via Toll-like receptor-4 (TLR-4) activation. Due to their pro-inflammatory properties, alarmins are supposed to enhance adaptive immunity via activation of dendritic cells (DCs). In contrast, analysing a model of allergic contact dermatitis (ACD) we observed a more severe disease outcome in Mrp8/14-deficient compared to wild-type mice. This unexpected...

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Identifiers

PMID: 23188082
DOI: 10.1038/emboj.2012.309
PMCID: PMC3545303

Genes

ACD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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