Differential response to benzylpenicillin in vivo of tolerant and non-tolerant variants of Streptococcus sanguis II.

doi:10.1093/jac/25.1.103

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Article

Differential response to benzylpenicillin in vivo of tolerant and non-tolerant variants of Streptococcus sanguis II.

The Journal of antimicrobial chemotherapy - 1 Jan 1990

Meeson J, McColm A A, Acred P, Greenwood D

Abstract excerpt

A variant that was highly tolerant to benzylpenicillin was obtained from a non-tolerant clinical isolate of Streptococcus sanguis II by repeated exposure to penicillin. The rabbit model of endocarditis was used to investigate the efficacy of a high dose regimen of benzylpenicillin (250 mg/kg; pea...

Topics

Drug Tolerance
Endocarditis, Bacterial
Genetic Variation
Penicillin G
Streptococcal Infections
Streptococcus sanguis

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