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Article

Functional FEN1 genetic variants and haplotypes are associated with glioma risk.

Journal of neuro-oncology - 1 Jan 2013

Chen Yi-Dong, Zhang Xiaojiao, Qiu Xiao-Guang, Li Jinpeng, Yuan Qipeng, Jiang Tao, Yang Ming

Abstract excerpt

As a tumor suppressor, FEN1 plays an essential role in keeping genomic instability and preventing tumorigenesis. There are two functional genetic variants (-69G>A and 4150G>T) in the FEN1 gene, which have been associated with DNA damage levels in coke-oven workers as well as risks of lung cancer, hepatocellular carcinoma, esophageal cancer, gastric cancer and colorectal cancer in general populations. However, it...

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Identifiers

PMID: 23184144
DOI: 10.1007/s11060-012-1007-0

Genes

FEN1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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